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Title: Desmosomes as signaling hubs in the regulation of cell behavior
Author(s): Müller, Lisa
Hatzfeld, Mechthild
Keil, René
Issue Date: 2021
Type: Article
Language: English
Abstract: Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to change cell behavior. Desmosome composition and size vary depending on tissue specific expression and differentiation state. Their constituent proteins are highly regulated by posttranslational modifications that control their function in the desmosome itself and in addition regulate a multitude of desmosome-independent functions. This review will summarize our current knowledge how signaling pathways that control epithelial shape, polarity and function regulate desmosomes and how desmosomal proteins transduce these signals to modulate cell behavior.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Frontiers in cell and developmental biology
Publisher: Frontiers Media
Publisher Place: Lausanne
Volume: 9
Original Publication: 10.3389/fcell.2021.745670
Appears in Collections:Open Access Publikationen der MLU

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