Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/108834
Title: | High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice |
Author(s): | Grundmann, Sarah Maria![]() Schutkowski, Alexandra Berger, Christian Bailer, Anja Christina ![]() König, Bettina Stangl, Gabriele I. ![]() |
Issue Date: | 2020 |
Type: | Article |
Language: | English |
Abstract: | The consumption of phosphorus in Western populations largely exceeds the recommended intake, while vitamin D supply is often insufficient. Both situations are linked to an increased cardiovascular risk. A 17-week two-factorial study with Ldl receptor-/- mice was conducted to investigate the cardiovascular impact of dietary phosphorus [adequate (0.3%; P0.3) vs. high (1.5%; P1.5)] in combination with a low (50 IU/kg; D50) or adequate vitamin D diet (1000 IU/kg; D1000). The data demonstrate that mice fed the P1.5 vs. P0.3 diets developed smaller vascular lesions (p = 0.013) and cardiac hypotrophy (p = 0.011), which were accompanied by diminished IGF1 and insulin signalling activity in their hearts. Vitamin D showed no independent effect on atherogenesis and heart morphology. Feeding P1.5 vs. P0.3 diets resulted in markedly reduced serum triacylglycerols (p < 0.0001) and cholesterol (p < 0.0001), higher faecal lipid excretion (p < 0.0001) and a reduced mRNA abundance of hepatic sterol exporters and lipoprotein receptors. Minor hypocholesterolaemic and hypotriglyceridaemic effects were also found in mice fed the D1000 vs. D50 diets (p = 0.048, p = 0.026). To conclude, a high phosphorus intake strongly affected the formation of vascular lesions, cardiac morphology, and lipid metabolism, although these changes are not indicative of an increased cardiovascular risk. |
URI: | https://opendata.uni-halle.de//handle/1981185920/110789 http://dx.doi.org/10.25673/108834 |
Open Access: | ![]() |
License: | ![]() |
Journal Title: | Scientific reports |
Publisher: | Macmillan Publishers Limited, part of Springer Nature |
Publisher Place: | [London] |
Volume: | 10 |
Original Publication: | 10.1038/s41598-020-77509-w |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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s41598-020-77509-w.pdf | 1.64 MB | Adobe PDF | ![]() View/Open |