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http://dx.doi.org/10.25673/110038
Titel: | Disruption of 24-hour rhythm in intraocular pressure correlates with retinal ganglion cell loss in glaucoma |
Autor(en): | Neroev, Vladimir Malishevskaya, Tatyana Weinert, Dietmar ![]() Astakhov, Sergei Kolomeichuk, Sergey Cornelissen, Germaine Kabitskaya, Yana Boiko, Elena Nemtsova, Irina Gubin, Denis |
Erscheinungsdatum: | 2021 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase of “marker” circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 participants (65 S-POAG and 50 A-POAG). Retinal Ganglion Cell (RGC) damage was assessed by high-definition optical coherence tomography. The 24-h IOP rhythm in A-POAG patients peaked during the night, opposite to the daytime phase position in S-POAG patients (p < 0.0001). The 24-h IOP phase correlated with RGC loss (p < 0.0001). The internal phase shift between IOP and body temperature gradually increased with POAG progression (p < 0.001). Angiotensin converting enzyme Alu-repeat deletion/insertion (ACE I/D) emerged as a candidate gene polymorphism, which may play a role in the alteration of the circadian IOP variability in advanced glaucoma. To conclude, a reliable estimation of the 24-h rhythm in IOP requires the degree of RGC damage to be assessed. In advanced POAG, the 24-h phase of IOP tended to occur during the night and correlated with RGC loss, being progressively delayed relative to the phase of temperature. |
URI: | https://opendata.uni-halle.de//handle/1981185920/111993 http://dx.doi.org/10.25673/110038 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Journal Titel: | International journal of molecular sciences |
Verlag: | Molecular Diversity Preservation International |
Verlagsort: | Basel |
Band: | 22 |
Heft: | 1 |
Originalveröffentlichung: | 10.3390/ijms22010359 |
Seitenanfang: | 1 |
Seitenende: | 18 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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ijms-22-00359.pdf | 2.24 MB | Adobe PDF | ![]() Öffnen/Anzeigen |