Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/115078
Title: | Blood β-synuclein is related to amyloid PET positivity in memory clinic patients |
Author(s): | Oeckl, Patrick![]() Bluma, Marina Bucci, Marco Halbgebauer, Steffen ![]() Chiotis, Konstantinos Sandebring-Matton, Anna Ashton, Nicholas J. Molfetta, Guglielmo Grötschel, Lana Kivipelto, Miia Blennow, Kaj Zetterberg, Henrik Savitcheva, Irina Nordberg, Agneta Otto, Markus ![]() |
Issue Date: | 2023 |
Type: | Article |
Language: | English |
Abstract: | Introduction: β-synuclein is an emerging blood biomarker to study synaptic degeneration in Alzheimer´s disease (AD), but its relation to amyloid-β (Αβ) pathology is unclear. Methods: We investigated the association of plasma β-synuclein levels with [18F]flutemetamol positron emission tomography (PET) in patients with AD dementia (n = 51), mild cognitive impairment (MCI–Aβ+ n = 18, MCI– Aβ– n = 30), non-AD dementias (n = 22), and non-demented controls (n = 5). Results: Plasma β-synuclein levels were higher in Aβ+ (AD dementia, MCI–Aβ+) than in Aβ– subjects (non-AD dementias, MCI–Aβ−) with good discrimination of Aβ+ from Aβ– subjects and prediction of Aβ status in MCI individuals. A positive correlation between plasma β-synuclein and Aβ PET was observed in multiple cortical regions across all lobes. Discussion: Plasma β-synuclein demonstrated discriminative properties for Aβ PET positive and negative subjects. Our data underline that β-synuclein is not a direct marker of Aβ pathology and suggest different longitudinal dynamics of synaptic degeneration versus amyloid deposition across the AD continuum. Highlights: Blood and CSF β-synuclein levels are higher in Aβ+ than in Aβ− subjects. Blood β-synuclein level correlates with amyloid PET positivity in multiple regions. Blood β-synuclein predicts Aβ status in MCI individuals. |
URI: | https://opendata.uni-halle.de//handle/1981185920/117034 http://dx.doi.org/10.25673/115078 |
Open Access: | ![]() |
License: | ![]() |
Journal Title: | Alzheimer's and dementia |
Publisher: | Wiley |
Publisher Place: | Hoboken, NJ |
Volume: | 19 |
Issue: | 11 |
Original Publication: | 10.1002/alz.13046 |
Page Start: | 4896 |
Page End: | 4907 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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Alzheimer s Dementia - 2023 - Oeckl - Blood ‐synuclein is related to amyloid PET positivity in memory clinic patients.pdf | 1.57 MB | Adobe PDF | ![]() View/Open |