Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/116117
Title: | The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients |
Author(s): | Belachew, Esmael Besufikad Desta, Adey Feleke Deneke, Dinikisira Bekele Gebremariam, Tewodros Yalew Tefera, Dessalegn Abeje Atire, Fikadu Alemu Alemayehu, Dawit Hailu Seyoum, Tamirayehu Bauer, Marcus ![]() Girma, Selfu Sewasew, Dareskedar Tsehay Kantelhardt, Eva Johanna ![]() Tesfaye Sisay Tessema ![]() Howe, Rawleigh |
Issue Date: | 2023 |
Type: | Article |
Language: | English |
Abstract: | Introduction: Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia. Materials and methods: A total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis. Results The MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0.012). Additionally, BC cases with positive lymph nodes and ER-positive receptors had higher MMP-11, MMP-9, and MMP-2 expression than cases with negative lymph nodes and ER-negative, respectively. The MMP-11 and MMP-9 expressions were higher in grade III and luminal A-like tumors than in grade I-II and other subtypes, respectively. Conclusion: The MMP-11 expression was higher in BC than in benign breast tumors. Additionally, MMP-11, MMP-9, and MMP-2 were higher in BC with positive lymph nodes and estrogen receptors. Our findings suggest an important impact of MMPs in BC pathophysiology, particularly MMP-11. |
URI: | https://opendata.uni-halle.de//handle/1981185920/118073 http://dx.doi.org/10.25673/116117 |
Open Access: | ![]() |
License: | ![]() |
Journal Title: | BMC Research Notes |
Publisher: | [Verlag nicht ermittelbar] |
Publisher Place: | London |
Volume: | 16 |
Original Publication: | 10.1186/s13104-023-06518-5 |
Appears in Collections: | Open Access Publikationen der MLU |
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s13104-023-06518-5.pdf | 1.11 MB | Adobe PDF | ![]() View/Open |