Calcium vs. Pentagastrin Stimulation bei der C-Zell-Erkrankung der Schilddrüse : eine Matched-Pair Analyse

Abstract

Calcitonin stimulation testing aims at defining the underlying type of c-cell disease (CCD) in order to customize appropriate timing and extent of surgery or consider observation. The importance of stimulation testing is widely accepted in hereditary CCD and the follow-up of MTC, while its role in sporadic forms is controversial. Importantly, calcium (Ca2+) stimulation testing lacks comparison to established recommendations based on reliable cut-off values using Pentagastrin (Pg). This study investigates the correlation of Ca2+- and Pg-stimulation testing in CCD. In a matched pair analysis, Pg- and Ca2+ -stimulation testing for calcitonin (Ct) was compared in 295 patients with c-cell hyperplasia (CCH) and with medullary thyroid cancer confined to the thyroid (Tx N0 M0) undergoing primary surgery.

Calcitonin stimulation testing aims at defining the underlying type of c-cell disease (CCD) in order to customize appropriate timing and extent of surgery or consider observation. The importance of stimulation testing is widely accepted in hereditary CCD and the follow-up of MTC, while its role in sporadic forms is controversial. Importantly, calcium (Ca2+) stimulation testing lacks comparison to established recommendations based on reliable cut-off values using Pentagastrin (Pg). This study investigates the correlation of Ca2+- and Pg-stimulation testing in CCD. In a matched pair analysis, Pg- and Ca2+ -stimulation testing for calcitonin (Ct) was compared in 295 patients with c-cell hyperplasia (CCH) and with medullary thyroid cancer confined to the thyroid (Tx N0 M0) undergoing primary surgery.