Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/78146| Title: | The presence of a cyclohexyldiamine moiety confers cytotoxicity to pentacyclic triterpenoids |
| Author(s): | Hoenke, Sophie Christoph, Martin A. Friedrich, Sander Heise, Niels Brandes, Benjamin Deigner, Hans-Peter Al-Harrasi, Ahmed Csuk, René |
| Issue Date: | 2021 |
| Type: | Article |
| Language: | English |
| Abstract: | Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a betulinic acid/trans-1,4-cyclohexyldiamine amide showed excellent cytotoxicity (for example, EC50 = 0.6 μM for HT29 colon adenocarcinoma cells). |
| URI: | https://opendata.uni-halle.de//handle/1981185920/80100 http://dx.doi.org/10.25673/78146 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Sponsor/Funder: | Publikationsfonds MLU |
| Journal Title: | Molecules |
| Publisher: | MDPI |
| Publisher Place: | Basel |
| Volume: | 26 |
| Issue: | 7 |
| Original Publication: | 10.3390/molecules26072102 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| molecules-26-02102-v2.pdf | 1.54 MB | Adobe PDF |  View/Open |