Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/78146
Title: | The presence of a cyclohexyldiamine moiety confers cytotoxicity to pentacyclic triterpenoids |
Author(s): | Hoenke, Sophie Christoph, Martin A. Friedrich, Sander Heise, Niels Brandes, Benjamin Deigner, Hans-Peter Al-Harrasi, Ahmed Csuk, René |
Issue Date: | 2021 |
Type: | Article |
Language: | English |
Abstract: | Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a betulinic acid/trans-1,4-cyclohexyldiamine amide showed excellent cytotoxicity (for example, EC50 = 0.6 μM for HT29 colon adenocarcinoma cells). |
URI: | https://opendata.uni-halle.de//handle/1981185920/80100 http://dx.doi.org/10.25673/78146 |
Open Access: | ![]() |
License: | ![]() |
Sponsor/Funder: | Publikationsfonds MLU |
Journal Title: | Molecules |
Publisher: | MDPI |
Publisher Place: | Basel |
Volume: | 26 |
Issue: | 7 |
Original Publication: | 10.3390/molecules26072102 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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molecules-26-02102-v2.pdf | 1.54 MB | Adobe PDF | ![]() View/Open |