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Title: The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients
Author(s): Belachew, Esmael Besufikad
Desta, Adey Feleke
Deneke, Dinikisira Bekele
Gebremariam, Tewodros Yalew
Tefera, Dessalegn Abeje
Atire, Fikadu Alemu
Alemayehu, Dawit Hailu
Seyoum, Tamirayehu
Bauer, MarcusLook up in the Integrated Authority File of the German National Library
Girma, Selfu
Sewasew, Dareskedar Tsehay
Kantelhardt, Eva JohannaLook up in the Integrated Authority File of the German National Library
Tesfaye Sisay TessemaLook up in the Integrated Authority File of the German National Library
Howe, Rawleigh
Issue Date: 2023
Type: Article
Language: English
Abstract: Introduction: Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia. Materials and methods: A total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis. Results The MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0.012). Additionally, BC cases with positive lymph nodes and ER-positive receptors had higher MMP-11, MMP-9, and MMP-2 expression than cases with negative lymph nodes and ER-negative, respectively. The MMP-11 and MMP-9 expressions were higher in grade III and luminal A-like tumors than in grade I-II and other subtypes, respectively. Conclusion: The MMP-11 expression was higher in BC than in benign breast tumors. Additionally, MMP-11, MMP-9, and MMP-2 were higher in BC with positive lymph nodes and estrogen receptors. Our findings suggest an important impact of MMPs in BC pathophysiology, particularly MMP-11.
Open Access: Open access publication
License: (CC0) Creative Commons Zero 1.0(CC0) Creative Commons Zero 1.0
Journal Title: BMC Research Notes
Publisher: [Verlag nicht ermittelbar]
Publisher Place: London
Volume: 16
Original Publication: 10.1186/s13104-023-06518-5
Appears in Collections:Open Access Publikationen der MLU

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