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Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/943
Title: The role of myocardin-related transcription factors in proliferation and cell cycle regulation of fibroblast cells
Author(s): Šapošnikov, Dmitrij
Advisor(s): Posern, Guido, Prof. Dr.
Wahle, Elmar, Prof. Dr.
Meister, Gunter, Prof. Dr.
Granting Institution: Martin-Luther-Universität Halle-Wittenberg
Issue Date: 2013
Extent: Online-Ressource (113 Bl. = 11,11 mb)
Type: Hochschulschrift
Exam Date: 31.07.2013
Language: English
Publisher: Universitäts- und Landesbibliothek Sachsen-Anhalt
URN: urn:nbn:de:gbv:3:4-10381
Subjects: Online-Publikation
Hochschulschrift
Abstract: Diese Doktorarbeit besteht aus mehreren Projekten, die die Rolle der Myocardin-ähnlichen Transkriptionsfaktoren (MRTFs) in kultivierten murinen Fibroblasten untersuchen. Die Ergebnisse dieser Studien zeigen zum ersten Mal die Verbindung zwischen MRTFs und der Regulation des Zellzyklus. Weiters werden die antiproliferatorischen Effekte von ektopisch exprimierten MRTFs analysiert, wobei zwei pro-apoptotische Gene, Bok und Noxa, als direkte Ziele von MRTF gefunden wurden.
The thesis is composed of several projects looking at the role of myocardin-related transcription factors (MRTFs) in cultured murine fibroblasts. Results of the studies included here show for the first time the connection between MRTFs and the regulation of cell cycle progression. Moreover, the anti-proliferative effects of MRTF's ectopic expression are analysed and two pro-apoptotic genes - Bok and Noxa - are established as direct MRTF targets.
URI: https://opendata.uni-halle.de//handle/1981185920/7842
http://dx.doi.org/10.25673/943
Open access: Open access publication
Appears in Collections:Biowissenschaften; Biologie

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