Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/110897| Title: | Photo-oxidation of therapeutic protein formulations : from radical formation to analytical techniques |
| Author(s): | Hipper, Elena Blech, Michaela  Hinderberger, Dariush Garidel, Patrick Kaiser, Wolfgang |
| Issue Date: | 2022 |
| Type: | Article |
| Language: | English |
| Abstract: | UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/112852 http://dx.doi.org/10.25673/110897 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Journal Title: | Pharmaceutics |
| Publisher: | MDPI |
| Publisher Place: | Basel |
| Volume: | 14 |
| Issue: | 1 |
| Original Publication: | 10.3390/pharmaceutics14010072 |
| Page Start: | 1 |
| Page End: | 50 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| pharmaceutics-14-00072-v3.pdf | 4.24 MB | Adobe PDF |  View/Open |