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http://dx.doi.org/10.25673/110897| Titel: | Photo-oxidation of therapeutic protein formulations : from radical formation to analytical techniques |
| Autor(en): | Hipper, Elena Blech, Michaela  Hinderberger, Dariush Garidel, Patrick Kaiser, Wolfgang |
| Erscheinungsdatum: | 2022 |
| Art: | Artikel |
| Sprache: | Englisch |
| Zusammenfassung: | UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/112852 http://dx.doi.org/10.25673/110897 |
| Open-Access: |  Open-Access-Publikation |
| Nutzungslizenz: |  (CC BY 4.0) Creative Commons Namensnennung 4.0 International |
| Journal Titel: | Pharmaceutics |
| Verlag: | MDPI |
| Verlagsort: | Basel |
| Band: | 14 |
| Heft: | 1 |
| Originalveröffentlichung: | 10.3390/pharmaceutics14010072 |
| Seitenanfang: | 1 |
| Seitenende: | 50 |
| Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| pharmaceutics-14-00072-v3.pdf | 4.24 MB | Adobe PDF |  Öffnen/Anzeigen |