Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/38264| Title: | What turns CREB on? And off? And why does it matter? |
| Author(s): | Steven, André Friedrich, Michael Jank, Paul Heimer, Nadine Budczies, Jan  Denkert, Carsten Seliger, Barbara |
| Issue Date: | 2020 |
| Type: | Article |
| Language: | English |
| Abstract: | Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/38507 http://dx.doi.org/10.25673/38264 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Sponsor/Funder: | Publikationsfond MLU |
| Journal Title: | Cellular and molecular life sciences |
| Publisher: | Springer International Publishing AG |
| Publisher Place: | Cham (ZG) |
| Volume: | 77 |
| Issue: | 20 |
| Original Publication: | 10.1007/s00018-020-03525-8 |
| Page Start: | 4049 |
| Page End: | 4067 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Steven2020_Article_WhatTurnsCREBOnAndOffAndWhyDoe.pdf | 2.14 MB | Adobe PDF |  View/Open |